BMS-599626 dihydrochloride

Description

BMS-599626 dihydrochloride is a small molecule pan-HER human epidermal growth factor receptor kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 IC50=20 nmol/L and HER2 IC50=30 nmol/L kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models.