BNN27

Description

BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis ALS model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis EAE model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable.