GENERAL CATALOGUE
BO-264
HY-135960 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-135960
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Catalog No: HY-135960
CAS No: 2408648-20-2
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 TACC3 inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint SAC -dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity.
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