GENERAL CATALOGUE
Borrelidin
HY-N6742 · 500 g
MedChemExpress · Cat: HY-N6742
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medchemexpress.com/borrelidin.htmlCatalog No: HY-N6742
CAS No: 7184-60-3
Category: Anti-infection
Pack Size: 500 g
Brand: MedChemExpress
Description
Borrelidin Treponemycin is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 ?M. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively.
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