Bortezomib (Standard)

Description

Bortezomib Standard is the analytical standard of Bortezomib. This product is intended for research and analytical applications. Bortezomib PS-341 is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome Ki=0.6 nM by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-?B. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma MM . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages TAMs .