

HY-162904 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-162904
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medchemexpress.com/bpu17.html
Description
BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition EMT of retinal pigment epithelial cells RPEs . BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration nAMD agent.







