GENERAL CATALOGUE
Bractoppin
HY-126020 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-126020
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medchemexpress.com/bractoppin.htmlCatalog No: HY-126020
CAS No: 2290527-07-8
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem t BRCT domain binding IC50: 74 nM . Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response.