BRD4-IN-11

Description

BRD4-IN-11 is an orally active and selective BRD4 inhibitor IC50 = 26.35 nM BD1 , IC50 = 72.81 nM BD2 . BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than againstBRD2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers ?-SMA and fibronectin , c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis.