GENERAL CATALOGUE
BRI-50460
HY-173371 · 5 mg
MedChemExpress · Cat: HY-173371
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Manufacturer product page
medchemexpress.com/bri-50460.htmlCatalog No: HY-173371
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
BRI-50460 is an inhibitor of cytosolic calcium-dependent phospholipase A2 cPLA2 that has the ability to penetrate the blood-brain barrier, with an IC50 of 0.88 nM. BRI-50460 exerts the activities of regulating neuroinflammation and restoring lipid homeostasis by inhibiting cPLA2, regulating the downstream inflammatory lipid signaling pathway, and alleviating the effects of amyloid ?42 oligomers on the activation of cPLA2, the hyperphosphorylation of tau protein, and the reduction of synapses and dendrites. BRI-50460 can be applied to the research in the fields of Alzheimers disease and other neurodegenerative diseases.
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