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BSJ-4-116
GENERAL CATALOGUE

BSJ-4-116

HY-139039 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-139039

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medchemexpress.com/bsj-4-116.html
Catalog No: HY-139039
CAS No: 2519823-34-6
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader PROTAC with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly adenylation . BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly ADP-ribose polymerase inhibitor Olaparib HY-10162 .

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