Bullatine A

Description

Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS HY-D1056 -induced systemic inflammatory response by inhibiting the ROS/JNK/NF-?B pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress CSDS mice. Bullatine A can be used for the study of inflammation, glioblastoma GBM and depression.