BVRA Stable Knockout Hepa1c1c7 Cell Line

Name: BVRA Stable Knockout Hepa1c1c7 Cell Line
Brand: abm good

T6282 · 1 x 106 cells / 1.0 mL

abm good · Cat: T6282

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Catalog No: T6282

Category: Cellular Materials

Pack Size: 1 x 106 cells / 1.0 mL

Brand: abm good

Description

BVRA biliverdin reductase A was knocked out of the mouse Hepa1c1c7 cells using sgRNAs inserted into the GuideIt-zsGreen plasmid. The plasmid was transfected and clones were selected via FACS sorting for fluorescence. Knockout was determined by qPCR and Western blot analysis. Studies have shown the loss of BVRA is associated with fat accumulation in livers of mice models. Therefore BVRA Stable Knockout Hepa1c1c7 Cell Line is useful to study the effects of BVRA and its association with obesity increased lipid availability and lipotoxicity in this liver cell line.