c-Kit/N705A Stable Ba/F3 Cell Line

Description

c-Kit or stem cell factor SCF receptor is a type III tyrosine kinase receptor that has a major role in the hematopoietic system and has nine key tyrosine residues. c-Kit/N705A-expressing Ba/F3 cells with GNNK- isoform has a N-to-A mutation at position 705, which results in reduced Cbl phosphorylation however, this mutation does not affect the activation of Src family kinases. The GNNK- isoform is the outcome of the c-Kit gene alternative splicing sites, resulting in different isoforms of the tetrapeptide GNNK, and is the main transcript found in human malignancies. Together with the wild-type c-Kit stable Ba/F3 cells Cat. No. T3041 and T3042 , these cells may be utilized in studies involving effects of asparagine residues on signaling pathways.