c-Kit/Y570F Stable Ba/F3 Cell Line

Description

c-Kit or stem cell factor SCF receptor is a type III tyrosine kinase receptor that has a major role in the hematopoietic system and has nine key tyrosine residues. Y570 residue, alongside with the Y568 residue, is involved in recruiting signaling molecules, and is part of the autoinhibition process of enzyme activity. c-Kit/Y570F-expressing Ba/F3 cells with GNNK- isoform has a Y-to-F mutation at position 570. The GNNK- isoform is the outcome of the c-Kit gene alternative splicing sites, resulting in different isoforms of the tetrapeptide GNNK, and is the main transcript found in human malignancies. It will proliferate in the presence of the ligand SCF, and activate downstream signal transduction. Together with the wild-type c-Kit stable Ba/F3 cells Cat. No. T3041 and T3042 and c-Kit/Y568F Stable Ba/F3 cells Cat. No. T3043 , these cells may be utilized in studies involving effects of tyrosine residues on signaling pathways.