c-Kit/Y703F Stable Ba/F3 Cell Line

Description

c-Kit or stem cell factor SCF receptor is a type III tyrosine kinase receptor that has a major role in the hematopoietic system and has nine key tyrosine residues. Y703 residue of the c-Kit receptor is involved in recruiting signaling molecules. c-Kit/Y703F-expressing Ba/F3 cells with GNNK- isoform has a Y-to-F mutation at position 703. The GNNK- isoform is the outcome of the c-Kit gene alternative splicing sites, resulting in different isoforms of the tetrapeptide GNNK, and is the main transcript found in human malignancies. Together with the wild-type c-Kit stable Ba/F3 cells Cat. No. T3041 and T3042 , these cells may be utilized in studies involving effects of tyrosine residues on signaling pathways.