c-MPL/Thrombopoietin R, His, Mouse

Description

The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV for myeloproliferative leukemia virus has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45 % of acute myeloid leukemia AML . No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.