

HY-168497 · 50 mg
MedChemExpress · Cat: HY-168497
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medchemexpress.com/c-ms023.html
Description
C-MS023 is a photo-activatable MS023 HY-19615 prodrug, achieving spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. C-MS023 inhibits PRMT6 mediated asymmetric dimethylation of H3 arginine 2 H3R2me2a , with an estimate IC50 of 0.2224 ?M. The photolysis of C-MS023 could be triggered by visible light irradiation at 420 nm, thereby liberating MS023 for effective downregulation of histone arginine asymmetric dimethylation and DNA replication-related transcriptomic activities.

