GENERAL CATALOGUE
C188
HY-112338 · 5 mg
MedChemExpress · Cat: HY-112338
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Catalog No: HY-112338
CAS No: 823828-18-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
C188 CPD188 is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding IC50 of 20 AAasAasAAmuM against pY-peptide binding and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation EC50s of 0.73 AAasAasAAmuM, 3.96 AAasAasAAmuM, and 7.01 AAasAasAAmuM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively .
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