C6 Urea Ceramide

Description

C6 Urea Ceramide Cer d18:1/6:0 Urea is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts MEFs and HT-29 colon cancer cells. C6 Urea Ceramide 5-10 ?M inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated ?-catenin levels in HT-29 and HCT116 cells, and induces colocalization of ?-catenin with the 20S proteasome. C6 Urea Ceramide 1.25, 2.5, and 5 mg/kg reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.