GENERAL CATALOGUE
Cabozantinib hydrochloride
HY-13016A · 50 mg
MedChemExpress · Cat: HY-13016A
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Manufacturer product page
medchemexpress.com/cabozantinib-hydrochloride.htmlCatalog No: HY-13016A
CAS No: 1817759-42-4
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Cabozantinib hydrochloride is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035 and 1.3 nM, respectively. Cabozantinib hydrochloride displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively . Cabozantinib hydrochloride shows antiangiogenic activity. Cabozantinib hydrochloride disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.
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