CAD031

Description

CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimers disease AD targeted agent J147 HY-13779 more active than J147 in human neural stem cell assays . CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimers disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice.