Candidusin A

Description

Candidusin A CHNQD-0803 Compound 4 is a AMPK activator with a KD of 47.28?nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells 22Rv1, PC-3 and LNCaP cells . Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-?B-TNF? inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis NASH research.