GENERAL CATALOGUE
Capmatinib dihydrochloride
HY-13404A · 5 mg
MedChemExpress · Cat: HY-13404A
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medchemexpress.com/capmatinib-dihydrochloride.htmlCatalog No: HY-13404A
CAS No: 1197376-85-4
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
Capmatinib INC280; INCB28060 dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor IC50=0.13 nM . Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase.
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