GENERAL CATALOGUE
Capmatinib dihydrochloride hydrate
HY-13404C · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-13404C
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Catalog No: HY-13404C
CAS No: 1865733-40-9
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Capmatinib INC280; INCB28060 dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor IC50=0.13 nM . Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase.
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