?-Casein (90-95) TFA

Description

?-Casein 90-95 TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. ?-Casein 90-95 TFA inhibits the secretion of ?-hexosaminidase by rat peritoneal mast cells PMC with IC50= 0.1 ?M. ?-Casein 90-95 TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC50 of 0.94 nM, 137 nM, and 6.92 nM, respectively. ?-Casein 90-95 TFA activates Gi-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. ?-Casein 90-95 TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer.