Phospho-Casein Kinase Iα (Tyr294) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-Casein Kinase Iα (Tyr294) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1L; Casein kinase I isoform alpha-like; CKI-alpha-like; CK1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 Background: CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. asein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed: 11955436, PubMed: 1409656, PubMed: 18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed: 23902688). asein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development. catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex., Research Area: WNT;WNT-T CELLHedgehog;