CAY10526

Description

CAY10526 is a specific microsomal PGE2 synthase-1 mPGES1 inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL anti-apoptotic protein levels and increases BAX and BAK pro-apoptotic as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability IC50<5 ?M in three melanoma cell lines expressing mPGES1.