GENERAL CATALOGUE
CAY10789
HY-147086 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-147086
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medchemexpress.com/cay10789.htmlCatalog No: HY-147086
CAS No: 123226-28-8
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CAY10789 is a potent CysLT1R cysteinyl leukotriene receptor 1 antagonist IC50=2.80 ?M and GPBAR1 G-protein-coupled bile acid receptor 1 agonist EC50=3 ?M . CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-?. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.
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