GENERAL CATALOGUE
CBR-5884
HY-100012 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-100012
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Catalog No: HY-100012
CAS No: 681159-27-3
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase PHGDH with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.
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