GENERAL CATALOGUE
CCG258747
HY-139690 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-139690
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medchemexpress.com/ccg258747.htmlCatalog No: HY-139690
CAS No: 2615910-00-2
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CCG258747 is a selective GRK2 inhibitor IC50 = 18 nM with high selectivity over GRK1, GRK5, PKA, and ROCK1 518, 83, 5500, and > 550-fold, respectively. CCG258747 also blocks the internalization of the AAasAasAAmu-opioid receptor MOR . CCG258747 attenuates IgE mediated anaphylaxis by inhibiting GRK2 and Fc?RI signaling pathway but activates mast cells via MRGPRX2 and MRGPRB2. CCG258747 can be used to study diseases related to overexpression of GRK2 such as heart failure, opioid tolerance .
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