CCND1 Mouse Monoclonal Antibody

Description

EnkiLife offers the CCND1 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for IHC,ICC,ELISA,FC application. Alternative Names of Immunogen: BCL1; PRAD1; U21B31; D11S287E. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:200-1:1000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Research Area: PI3K-Akt signaling pathway