GENERAL CATALOGUE
CCT128930 hydrochloride
HY-13260A · 5 mg
MedChemExpress · Cat: HY-13260A
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medchemexpress.com/cct128930-hydrochloride.htmlCatalog No: HY-13260A
CAS No: 2453324-32-6
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
CCT128930 hydrochloride is a potent and selective inhibitor of AKT IC50=6 nM . CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase IC50=168 nM through the targeting of Met282 of AKT Met173 of PKA-AKT chimera , as well as 20-fold selectivity over p70S6K IC50=120 nM . CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity.
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