

HY-174395 · 50 mg
MedChemExpress · Cat: HY-174395
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medchemexpress.com/cd-10.html
Description
CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction PPI inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress CUMS mouse model. CD-10 can be used for the study of depression.







