CD275 Rabbit Polyclonal Antibody

Description

EnkiLife offers the CD275 Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: ICOS ligand (B7 homolog 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7RP-1;CD antigen CD275). The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:200,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 Background: alternative products:Additional isoforms seem to exist,function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells. sequence caution:The sequence differs from that shown in position 300 onward for unknown reason. sequence caution:Translation N-terminally shortened. similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family. similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. Research Area:Cell adhesion molecules (CAMs);Intestinal immune network for IgA production;