CD73-IN-19

Description

CD73-IN-19 Compound 4ab is a CD73 inhibitor with a 44 % inhibition rate of CD73 enzymatic activity at 100 ?M . CD73-IN-19 at 10 ?M and 100 ?M can completely antagonize the blockade of T cell proliferation induced by TCR T cell receptor triggering which is induced by CD73 activity , and it can also inhibit the hA2A receptor activity in HEK-293 cells Ki is 3.31 ?M . CD73-IN-19 holds promise for research in the field of immune diseases.