CD89 Rabbit Polyclonal Antibody

Description

EnkiLife offers the CD89 Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 Background: This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],alternative products:Additional isoforms seem to exist,function:Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.,tissue specificity:Differentially expressed between blood and mucosal myeloid cells. Monocytes express isoform A.1, isoform A.2 and isoform A.3 while alveolar macrophages express isoform A.1 and isoform A.2; however they express only one isoform at their surfaces.,