CDDO-TFEA

Description

CDDO-TFEA RTA 404; TP-500 is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntingtons disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewings sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.