GENERAL CATALOGUE
CDK-IN-9
HY-150641 · 1 mg
MedChemExpress · Cat: HY-150641
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Catalog No: HY-150641
CAS No: 3031561-92-6
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
CDK-IN-9 compound 24 is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II.
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