

HY-112626 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112626
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medchemexpress.com/cdk12-in-2.htmlDescription
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor IC50=52 nM with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.





