GENERAL CATALOGUE
CDK12-IN-8
HY-171786 · 50 mg
MedChemExpress · Cat: HY-171786
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medchemexpress.com/cdk12-in-8.htmlCatalog No: HY-171786
CAS No: 2928619-86-5
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
CDK12-IN-8 Compound Cpd143 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 CDK12 . CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain CTD serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer.
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