GENERAL CATALOGUE
CDK2-IN-42
HY-173147 · 50 mg
MedChemExpress · Cat: HY-173147
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medchemexpress.com/cdk2-in-42.html
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Catalog No: HY-173147
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
CDK2-IN-42 Compound H63 is a CDK12 inhibitor with an IC50 value of 10 nM. CDK2-IN-42 has anti-ESCC Esophageal Squamous Cell Carcinoma cell activity. It can block transcriptional elongation, downregulate the core genes in the G1 phase to induce cell cycle arrest, and alter the CDK12-ATM/ATR-CHEK1/CHEK2 signaling axis, resulting in DNA damage. CDK2-IN-42 can effectively inhibit tumor growth in a xenograft mouse model of human ESCC KYSE150. CDK2-IN-42 holds great promise for research in the field of cancer.
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