CDK4 Antibody, mAb, Rabbit

Description

Ser/Thr-kinase component of cyclin D-CDK4 DC complexes that phosphorylate and inhibit members of the retinoblastoma RB protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.