GENERAL CATALOGUE
CDK6/PIM1-IN-1 hydrochloride
HY-142696A · 5 mg
MedChemExpress · Cat: HY-142696A
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medchemexpress.com/cdk6-pim1-in-1-hydrochloride.html
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Catalog No: HY-142696A
CAS No: 2677026-15-0
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
CDK6/PIM1-IN-1 Compound 51 hydrochloride is an orally active and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 IC50=3.6 nM . CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia AML cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity.
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