GENERAL CATALOGUE
CDK8-IN-16
HY-171174 · 1 mg
MedChemExpress · Cat: HY-171174
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medchemexpress.com/cdk8-in-16.htmlCatalog No: HY-171174
CAS No: 1860885-61-5
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
CDK8-IN-16 Compound 51 is an orally active dual inhibitor for CDK8 and CDK19 wih IC50 of 5.1 nM and 5.6 nM. CDK8-IN-16 inhibits the phospho-STAT1SER727 with an IC50 of 17.9 nM in SW620 cell, inhibits WNT signaling pathway with an IC50 of 7.2 nM in 7dF3 cell. CDK8-IN-16 exhibits good pharmacokinetic characteristics in rat models with an oral bioavailability of 57 %.
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