GENERAL CATALOGUE
CDK9 degrader-1
HY-176451 · 50 mg
MedChemExpress · Cat: HY-176451
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medchemexpress.com/cdk9-degrader-1.htmlCatalog No: HY-176451
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
CDK9 degrader-1 Compound AZ-9 is a selective CDK9 degrader DC50: 0.4073 AAasAasAAmuM . CDK9 degrader-1 recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuses with lysosomes to degrade CDK9 and its partner protein Cyclin T1 DC50: 1.215 AAasAasAAmuM . CDK9 degrader-1 induces caspase 3-mediated apoptosis. CDK9 degrader-1 has antitumor activity in a mouse HCT116 xenograft model.
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