GENERAL CATALOGUE
CDKI-83
HY-123034 · 50 mg
MedChemExpress · Cat: HY-123034
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medchemexpress.com/cdki-83.html
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Catalog No: HY-123034
CAS No: 1189558-88-0
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
CDKI-83 is a potent CDK9 and CDK1 inhibitor with Ki values of 21 nM and 72 nM for CDK9/T1 and CDK1/B, respectively. CDKI-83 demonstrates effective anti-proliferative activity in human tumour cell lines with a GI50 1 ?M. CDKI-83 effectively induces apoptosis in A2780 human ovarian cancer cells. CDKI-83 reduces phosphorylation at Ser-2 of RNA polymerase II RNAPII by inhibiting cellular CDK9 activity, and down-regulates Mcl-1 and Bcl-2. CDKI-83 has the potential for anti-cancer research.
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