Cefotetan

Description

Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein hRKIP . Cefotetan binds to hRKIP, reduces the binding space between hRKIP and Raf1 kinase, relieves hRKIPs inhibition of the Ras/Raf1/MEK/ERK signaling pathway, and enhances ERK phosphorylation. Cefotetan can be used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways. Cefotetan is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins PBPs . It is used to study bacterial infections such as bone, skin, urinary tract, and lower respiratory tract.