Ceramide 3-d3

Description

Ceramide 3-d3 N-Stearoyl phytosphingosine-d3 is deuterium labeled Ceramide 3. C18 Phytoceramide t18:0/18:0 Cer t18:0/18:0 is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer t18:0/18:0 consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer t18:0/18:0 has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-?, and transcription factors c-Jun and NF-?B in histone-stimulated mouse skin tissue. Formulations containing cer t18:0/18:0 have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.