GENERAL CATALOGUE
CF53
HY-112610 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112610
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medchemexpress.com/CF53.html
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Catalog No: HY-112610
CAS No: 1808160-52-2
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.
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