GENERAL CATALOGUE
CFT8634
HY-145925B · 1 mg
MedChemExpress · Cat: HY-145925B
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Catalog No: HY-145925B
CAS No: 2704617-96-7
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors Pink: BRD9 ligand HY-169988 ; Blue: E3 ligase ligand HY-169989 ; Black: linker HY-169991 . CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers such as synovial sarcoma and malignant rhabdoid tumor .
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